The package dcmtk provides CMake targets: find_package(DCMTK CONFIG REQUIRED) # Note: 23 target(s) were omitted. target_link_libraries(main PRIVATE cmr i2d ijg8 dcmfg) Add the following cmake code to your CMakeLists.txt to create definitions for DCMTK if ("${VCPKG_INSTALLED_DIR}/${VCPKG_TARGET_TRIPLET}" STREQUAL "/") message(WARNING "No vcpkg install dir found, DCMTK definitions are not set") else() target_compile_definitions(main PUBLIC "DCMTK_PREFIX=${VCPKG_INSTALLED_DIR}/${VCPKG_TARGET_TRIPLET}" "DCM_DICT_DEFAULT_PATH=${VCPKG_INSTALLED_DIR}/${VCPKG_TARGET_TRIPLET}/share/dcmtk/dicom.dic:${VCPKG_INSTALLED_DIR}/${VCPKG_TARGET_TRIPLET}/share/dcmtk/private.dic" "DEFAULT_CONFIGURATION_DIR=${VCPKG_INSTALLED_DIR}/${VCPKG_TARGET_TRIPLET}/etc/dcmtk/" "DEFAULT_SUPPORT_DATA_DIR=${VCPKG_INSTALLED_DIR}/${VCPKG_TARGET_TRIPLET}/share/dcmtk/" ) endif()