The package python3 provides a python interpreter that supports virtual environments: $ tools/python3/python3.10 -m venv /path/to/venv $ export VIRTUAL_ENV=/path/to/venv $ export PATH=/path/to/venv/bin:$PATH $ export -n PYTHONHOME $ unset PYTHONHOME See https://docs.python.org/3/library/venv.html for more details.